Cenozoic plate driving forces

Past studies of plate driving forces have concluded that the forces due to subducted slabs in the upper mantle and those due to the thickening of the oceanic lithosphere are the principal driving forces. We reexamine the balance of driving forces for the present-day and extend our analysis through the Cenozoic, using an analytical torque balance method which accounts for interactions between plates via viscous coupling to the induced mantle flow, We use an evolving mantle density heterogeneity field based on the last 200 Myr. of subduction to drive plate motions, an approach which has proven successful in predicting the present-day mantle heterogeneity field. We find that for plausible upper mantle viscosities the forces due to subducted slabs in the Cenozoic and Mesozoic account for in excess of 90% of plate driving forces and those due to lithospheric thickening for less than 10%

Method and apparatus for optical modulating a light signal Patent

Method and apparatus for optically modulating light or microwave bea

Site-saturation studies of β-lactamase: Production and characterization of mutant β-lactamases with all possible amino acid substitutions at residue 71

A mutagenic technique that "saturates" a particular site in a protein with all possible amino acid substitutions was used to study the role of residue 71 in β-lactamase (EC 3.5.2.6). Threonine is conserved at residue 71 in all class A β-lactamases and is adjacent to the active site Ser-70. All 19 mutants of the enzyme were characterized by the penam and cephem antibiotic resistance they provided to Escherichia coli LS1 cells. Surprisingly, cells producing any of 14 of the mutant β-lactamases displayed appreciable resistance to ampicillin; only cells with mutants having Tyr, Trp, Asp, Lys, or Arg at residue 71 had no observable resistance to ampicillin. However, the mutants are less stable to cellular proteases than wild-type enzyme is. These results suggest that Thr-71 is not essential for binding or catalysis but is important for stability of the β-lactamase protein. An apparent change in specificity indicates that residue 71 influences the region of the protein that accommodates the side chain attached to the β-lactam ring of the substrate

Visual Attention to Radar Displays

A model is described which predicts the allocation of attention to the features of a radar display. It uses the growth of uncertainty and the probability of near collision to call the eye to a feature of the display. The main source of uncertainty is forgetting following a fixation, which is modelled as a two dimensional diffusion process. The model was used to predict information overload in intercept controllers, and preliminary validation obtained by recording eye movements of intercept controllers in simulated and live (practice) interception

Self-injurious behaviour in individuals with autism spectrum disorder

Background: Autism spectrum disorder (ASD) has been identified as a risk marker for self-injurious behaviour. In this study we aimed to describe the prevalence, topography and correlates of self-injury in individuals with ASD in contrast to individuals with Fragile X and Down syndromes and examine person characteristics associated with self-injury across and within these groups.\ud \ud Method: Carers of individuals with ASD (N=149; mean age=9.98, SD=4.86), Fragile X syndrome (N=123; mean age=15.32, SD=8.74) and Down syndrome (N=49; mean age=15.84, SD=12.59) completed questionnaires relating to the presence and topography of self-injury Information was also gathered regarding demographic characteristics, affect, autistic behaviour, hyperactivity, impulsivity and repetitive behaviour.\ud \ud Results: Self-injurious behaviour was displayed by 50% of the ASD sample; a significantly higher prevalence than in the Down syndrome group (18.4%) but broadly similar to the prevalence in Fragile X syndrome (54.5%). Self-injury was associated with significantly higher levels of autistic behaviour within the Down and Fragile X syndrome groups. Within the ASD group, the presence of self-injury was associated with significantly higher levels of impulsivity and hyperactivity, negative affect and significantly lower levels of ability and speech.\ud \ud Conclusions: Self-injurious behaviour is prevalent in individuals with ASD and the presence of ASD phenomenology increases the risk of self-injury in individuals with known genetic disorders but without a diagnosis of idiopathic autism. Person characteristics associated with self-injury in ASD indicate a role for impaired behavioural inhibition, low levels of ability and negative affect in the development of self-injurious behaviour

Optically induced free carrier light modulator

Signal carrier laser beam is optically modulated by a second laser beam of different frequency acting on a free carrier source to which the signal carrier laser is directed. The second laser beam affects the transmission characteristics of the free carrier source to light from the signal carrier laser, thus modulating it

A survey of occupational therapy practitioners in mental health

As part of the College of Occupational Therapists’ Mental Health Project, a survey of occupational therapists practising in mental health in the UK was conducted. A questionnaire was sent to 200 members of the Association of Occupational Therapists in Mental Health and achieved a 68.5% response rate. The majority of the 137 respondents were female, with Senior I staff between 20 and 30 years of age who were unlikely to have worked in another area forming the largest group. Although most had received additional training, they identified the need for more training, especially in aspects of occupational therapy. Most were managed by an occupational therapist and 96% received supervision. Community mental health was the most frequently reported area of work with leisure, counselling, anxiety management and creative activities the most frequently used interventions. Respondents were committed to the core principles of occupational therapy and the need to develop outcome measures and evidence based practice, and were concerned about moves to generic working. This study has provided data, not only for the position paper on the way ahead for occupational therapy in mental health but also for individual occupational therapists and managers

Supply chain control: Trade-offs and system requirements

The official published version can be accessed from the link below.A paper describes the underlying forces which drive change in manufacturing enterprises and supply chains. It sets out the complexities in modern capitalism and global economics and illustrates the trade-offs that can be made. IT systems which are required to assist improvements to both customer service and enterprise manufacturing performance are explained, alluding to the special case for the semiconductor industry. Arguments are presented showing how the new tools being developed with the ESPRIT project 20544, X-CITTIC, will satisfy the control needs for a virtual enterprise. This paper describes the underlying forces which drive change in manufacturing enterprises and supply chains. It sets out the complexities in modem capitalism and global economics and illustrates the trade-offs that can be made. IT systems which are required to assist improvements to both customer service and enterprise manufacturing performance are explained alluding to the special case for the semiconductor industry. Finally it shows how the new tools being developed with the ESPRIT project 20544, XCITTIC, will satisfy the control needs for a virtual enterprise